Users Discontinuing Slimming Injections Put On Pounds Far More Rapidly Than Dieters
A recent study suggests that people who come off popular weight-loss injections like semaglutide or tirzepatide may regain lost weight much more quickly than those who end conventional lifestyle programs.
Findings released in a major medical journal shows that while overweight people frequently drop a large proportion of their body weight while undergoing treatment, the weight comes back at an average rate of nearly a kilo each month upon discontinuation.
"Individuals buying these drugs should be cognizant of the danger of fast weight regain when the medication ends," cautioned lead investigator Dr. Susan Jebb.
That rate of regain suggests a return to pre-treatment weight in about 18 months.
Analyzing Treatments
The study, which looked at dozens of trials involving over 9,000 of participants, contrasted the results of these new drugs with conventional dieting.
The team point out that individuals who lose weight through dieting usually experience a slower creep back—approximately 0.1 kg a month—once they finish.
Explaining the Rapid Regain
Experts suggest the way of the drugs accounts for the amplified rebound.
These medications mimic a body's own chemical called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Long-term administration of the hormone levels several times higher than normal may cause the system to generate a reduced amount of its endogenous GLP-1, and could reduce sensitivity to its actions," explained Dr. Adam Collins, a dietetics specialist.
"Withdrawal of this hormone supplement means hunger is unsuppressed, making binge eating much more probable."
A Lifelong Issue?
Health authorities recommend the jabs for people with obesity-related health risks, accompanied by recommended diet and exercise modifications.
A number of clinicians contend that, considering the significant potential of relapse, the treatment should be considered ongoing.
This opinion is reinforced by pharmaceutical companies, who say that the findings "highlight the chronic character of obesity," similar to managing diseases like high blood pressure.
Patient Experiences
Individuals who have come off the medication explain a powerful return of appetite.
"It felt as if a switch activating and I was suddenly ravenous," described an individual.
The struggle is exacerbated if users have not developed permanent lifestyle or habit modifications during treatment.
Widespread Adoption
Figures show that a significant number of adults in the UK have tried these injections in the last 12 months, with desire remaining high.
- Adoption is higher among women than males.
- The middle-aged demographic shows the highest usage rates.
- Many obtain the medications through private prescriptions rather than public health services.
In conclusion, experts caution that while the jabs are powerful agents for shedding pounds, they are not a permanent cure and long-term success likely depends on combined behavioural support.